If you’ve tried Motilium (domperidone) and want something else—maybe it didn’t work, caused side effects, or you can’t get a prescription—there are plenty of other ways to calm an upset stomach. Below we’ll break down why people look for substitutes and which over‑the‑counter (OTC) options actually help.
Motilium is popular because it speeds up the movement of food through your gut, but it can raise heart rhythm concerns and isn’t approved everywhere. Some pharmacies even require a doctor’s note. If you’ve experienced headaches, dizziness, or simply can’t find a licensed source, swapping to an OTC product saves time and cuts risk.
1. Metoclopramide (Reglan) – low‑dose OTC versions: In many countries a low dose is sold without prescription. It works similarly to Motilium by boosting stomach muscle contractions, but watch for drowsiness.
2. Ondansetron (Zofran) – OTC kits: Often marketed as “anti‑vomit tablets” for chemo patients, small packs are now legal in some regions. It blocks the nausea signal in the brain and is gentle on the heart.
3. Ginger supplements: Fresh ginger tea or capsules can settle the stomach within minutes. The active compounds speed up gastric emptying and are safe for most people.
4. Vitamin B6 (Pyridoxine): A daily 25‑mg dose has been shown to reduce morning sickness and motion‑induced nausea without any prescription.
5. Antihistamines like Meclizine or Dimenhydrinate: These are great for travel‑related nausea. They don’t speed digestion but calm the inner ear signals that trigger vomiting.
6. Prochlorperazine (Compazine) – OTC eye drop formula: Some pharmacies sell a low‑strength version as an eye drop that can be taken orally for short‑term relief. It’s potent, so only use under guidance.
When choosing any of these, read the label for dosage limits and interactions with other meds you might be taking. If you have heart problems, steer clear of anything that can affect rhythm—stick to ginger or vitamin B6 instead.
Buying safely matters too. Look for Canadian‑verified online pharmacies, check for a CIPA seal, and avoid sites promising “miracle pills” at rock‑bottom prices. A reputable pharmacy will ask for a prescription when needed and use secure payment methods.
Finally, remember lifestyle tricks: stay hydrated, eat small bland meals, and avoid strong smells. Combining an OTC anti‑nausea pill with these habits often clears symptoms faster than medication alone.
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